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NEWS

Park Lab since 2018

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We're hiring!! (6/1/2024 updated)

June 01, 2024

#research_assistant (1 opening)
: a full-time position to provide scientific and technical assistance to complete research projects on molecular tool development to study protein synthesis, synaptic plasticity, learning, and memory.
: Bachelor’s degree and basic lab skills in an area of biological sciences are required.
: If interested, email your CV and a concise description of your research interest to joongkyu.park@wayne.edu.
: you can also directly apply via https://waynetalent.csod.com/ux/ats/careersite/2/home/requisition/2039?c=waynetalent

#lab_manager (1 opening)
: a part-time position to provide technical and administrative assistance and maintain research equipment, supplies, reagents, etc.
: Bachelor’s degree and basic lab skills in an area of biological sciences are required.
: If interested, email your CV and a concise description of your managing experience to joongkyu.park@wayne.edu.

#graduate_students
: graduate students who are highly motivated to study molecular, cellular, and/or behavioral neuroscience (through the Department of Pharmacology, Wayne State University) are highly encouraged to email joongkyu.park@wayne.edu.
: details are available at https://pharmacology.med.wayne.edu/pharm-phd

#postdoc
: no opening is available at this moment.

Please email to joongkyu.park@wayne.edu for general inquiries.

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Chan Zuckerberg Initiative (CZI) Neurodegeneration Challenge Network (NDCN) Collaborative Pairs Pilot Grant awarded!

February 21, 2024

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Anna is awarded the 2023 Society for Neuroscience Trainee Professional Development Award! Congrats!

Aug 29, 2023

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NARSAD Young Investigator Grant awarded!

August 17, 2023

Thrilled to announce that we have been awarded NARSAD Young Investigator Grant for our ongoing research. We appreciate the significant support from the Brain & Behavior Research Foundation (www.bbrfoundation.org).

Link: https://www.bbrfoundation.org/sites/default/files/pdfs/2023-yi-booklet.pdf
Link: https://pharmacology.med.wayne.edu/news/dr-park-selected-for-the-2023-narsad-young-investigator-grant-53955

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New paper is out!

July 19, 2023

Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.

Park J, Berthoux C, Hoyos-Ramirez E, Shan L, Morimoto-Tomita M, Wang Y, Castillo PE, Tomita S.

Cell Rep (2023) 42: 112826. doi: 10.1016/j.celrep.2023.112826 PMID: 37471228

"Here, we report the development of a chemogenetic tool, ExSYTE (Excitatory SYnaptic Transmission modulator by Engineered TARPγ-8), to mimic the cytoplasmic interaction of TARP with the plasma membrane in a doxycycline-dependent manner."

"Thus, chemogenetic controlling of the TARP-membrane interaction is sufficient for LTP-like synaptic AMPAR insertion, which mimics fear conditioning."

Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00837-9
Link: https://pharmacology.med.wayne.edu/news/new-tool-to-mimic-synaptic-plasticity-dr-joongkyu-park-lab-53794

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New collaboration paper is out!

July 13, 2023

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.

Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Farese RV Jr, Walther TC.

Nat Cell Biol (2023) doi: https://doi.org/10.1038/s41556-023-01178-w

"Here we identify spartin as a receptor localizing to LDs and interacting with core autophagy machinery, and we show that spartin is required to deliver LDs to lysosomes for triglyceride mobilization."

"Interfering with spartin function in cultured human neurons or murine brain neurons leads to LD and triglyceride accumulation."

"Our identification of spartin as a lipophagy receptor, thus, suggests that impaired LD turnover contributes to Troyer syndrome development."

Link: https://www.nature.com/articles/s41556-023-01178-w

Highlighted in: https://www.science.org/doi/10.1126/science.add3509
Highlighted in: https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2247311
Highlighted in: https://www.science.org/doi/full/10.1126/scisignal.adk7152

Link: https://pharmacology.med.wayne.edu/news/a-lipophagy-receptor-in-neurons-dr-joongkyu-park-lab-53755

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Anna is selected as NIH-funded Chemistry Biology Interface (CBI) Scholar for the 2023-2024! Congrats!

2023

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Michigan Alzheimer's Disease Center (MADC) Developmental Project awarded!

Mar 7, 2023

Thrilled to announce that we have been awarded Michigan Alzheimer's Disease Center (MADC) Developmental Project grant for our ongoing AD research. We appreciate the significant support from MADC/MADRC (https://alzheimers.med.umich.edu/).

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Alzheimer's Association Research Grant (AARG) awarded!

Feb 22, 2023

Thrilled to announce that we have been awarded an Alzheimer's Association Research Grant (AARG) for our ongoing research. With this support, we aim to understand how compartmental protein demand and homeostasis are modified in Alzheimer’s disease models. We appreciate the significant support from the Alzheimer's Association (www.alz.org). #ENDALZ

Link: https://today.wayne.edu/medicine/news/2023/05/30/alzheimers-association-supports-synaptic-research-by-school-of-medicines-joongkyu-park-phd-53509

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Anna is awarded WSU Pharmacology SNAP funding! Congrats!

Jan 27, 2023

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Bridget is selected as a recipient of the 2023 UROP Winter-Spring/Summer Award! Congrats!

Jan 19, 2023

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Anna is selected as the Pharmacology Image Contest Winners! Congrats!

Aug 29, 2022

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Anna is selected as a recipient of the Corrine F. Resta Endowed Doctoral Support Award! Congrats!

Aug 25, 2022

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New paper is out!

August 19, 2022

NMDA receptor-targeted enrichment of CaMKIIα improves fear memory.

Chifor A, Choi J, Park J.

iScience (2022) 25: 104864. doi:10.1016/j.isci.2022.104864

"Capitalizing on the fact that long-term potentiation requires N-methyl-D-aspartate receptors (NMDARs) and Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα), we develop an intrabody that targets NMDARs and show that intrabody-mediated postsynaptic enrichment of CaMKIIα in the hippocampus improves contextual fear memory. "

https://pubmed.ncbi.nlm.nih.gov/35996578/

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Joongkyu is selected as a recipient of the Isadore & Margaret Mezey Junior Investigator Conference Award. Congrats!

May 2, 2022

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Sana is inducted into Phi Beta Kappa, the oldest academic honor society in the US! Congrats!

2022

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Anna is selected as NIH-funded Chemistry Biology Interface (CBI) Scholar for the 2022-2023! Congrats!

2022

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Anthony won the 1st Place in the Basic Science Research of the 2022 Medical Student Research Symposium! Congrats!

February 15, 2021

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Anthony's got the WSU SOM 2021 Medical Student Research Fellowship! Congrats!

May 21, 2021

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Anthony is the 1st Place Winner of Basic Science Research of the 2021 Medical Student Research Virtual Symposium!

February 12, 2021

The 2021 Medical Student Research Virtual Symposium at Wayne State University School of Medicine announced today that Anthony Chifor is the recipient of the 1st place winner of the Basic Science Research for the development of novel, genetically encoded tools. Congratulations, Anthony!

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New paper is out!

October 08, 2018

Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity.
Park J.
Proteomes (2018) 6: 40. Review. doi: 10.3390/proteomes6040040
• Special Issue "Neuroproteomics"

"This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity."

https://pubmed.ncbi.nlm.nih.gov/30297624/

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Park lab is open!

September 01, 2018

Park lab (www.synapsepark.com) is open! We start an adventure to understand synaptic molecular dynamics underlying normal and pathological behavioral processes.

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