Park Lab since 2018
AKN Junior Faculty Award awarded!
October 7, 2024
Very excited to announce that Joongkyu was awarded the Association of Korean Neuroscientists (AKN) Junior Faculty Award.
NIH/NIA R01 and R21 grants awarded!
September 1, 2024
Thrilled to announce that we have been awarded a R01 grant (R01AG089566) and a R21 grant (R21AG083760). We appreciate the significant support from the National Institutes of Health (NIH)/National Institute on Aging (NIA).
Chan Zuckerberg Initiative (CZI) Neurodegeneration Challenge Network (NDCN) Collaborative Pairs Pilot Grant awarded!
February 21, 2024
Thrilled to announce that we have been awarded CZI NDCN Collaborative Pairs Pilot Grant for our collaboration with Dr. Jeeyun Chung's lab (Harvard University; https://www.jeeyunchunglab.org). We appreciate the significant support from the CZI (https://chanzuckerberg.com).
Link: https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/?award=collaborative-pairs-pilot-project-cycle-2-phase-1
Link: https://pharmacology.med.wayne.edu/news/dr-joongkyu-parks-interdisciplinary-and-inter-institutional-partnership-wins-support-from-chan-zuckerberg-initiative-61663
Link: https://www.mcb.harvard.edu/department/news/interdisciplinary-and-inter-institutional-partnership-studying-neurodegenerative-diseases-wins-support-from-chan-zuckerberg-initiative/
Anna is awarded the 2023 Society for Neuroscience Trainee Professional Development Award! Congrats!
Aug 29, 2023
NARSAD Young Investigator Grant awarded!
August 17, 2023
Thrilled to announce that we have been awarded NARSAD Young Investigator Grant for our ongoing research. We appreciate the significant support from the Brain & Behavior Research Foundation (www.bbrfoundation.org).
Link: https://www.bbrfoundation.org/sites/default/files/pdfs/2023-yi-booklet.pdf
Link: https://pharmacology.med.wayne.edu/news/dr-park-selected-for-the-2023-narsad-young-investigator-grant-53955
New paper is out!
July 19, 2023
Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.
Park J, Berthoux C, Hoyos-Ramirez E, Shan L, Morimoto-Tomita M, Wang Y, Castillo PE, Tomita S.
Cell Rep (2023) 42: 112826. doi: 10.1016/j.celrep.2023.112826 PMID: 37471228
"Here, we report the development of a chemogenetic tool, ExSYTE (Excitatory SYnaptic Transmission modulator by Engineered TARPγ-8), to mimic the cytoplasmic interaction of TARP with the plasma membrane in a doxycycline-dependent manner."
"Thus, chemogenetic controlling of the TARP-membrane interaction is sufficient for LTP-like synaptic AMPAR insertion, which mimics fear conditioning."
Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00837-9
Link: https://pharmacology.med.wayne.edu/news/new-tool-to-mimic-synaptic-plasticity-dr-joongkyu-park-lab-53794
New collaboration paper is out!
July 13, 2023
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.
Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Farese RV Jr, Walther TC.
Nat Cell Biol (2023) doi: https://doi.org/10.1038/s41556-023-01178-w
"Here we identify spartin as a receptor localizing to LDs and interacting with core autophagy machinery, and we show that spartin is required to deliver LDs to lysosomes for triglyceride mobilization."
"Interfering with spartin function in cultured human neurons or murine brain neurons leads to LD and triglyceride accumulation."
"Our identification of spartin as a lipophagy receptor, thus, suggests that impaired LD turnover contributes to Troyer syndrome development."
Link: https://www.nature.com/articles/s41556-023-01178-w
Highlighted in: https://www.science.org/doi/10.1126/science.add3509
Highlighted in: https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2247311
Highlighted in: https://www.science.org/doi/full/10.1126/scisignal.adk7152
Link: https://pharmacology.med.wayne.edu/news/a-lipophagy-receptor-in-neurons-dr-joongkyu-park-lab-53755
Anna is selected as NIH-funded Chemistry Biology Interface (CBI) Scholar for the 2023-2024! Congrats!
2023
Michigan Alzheimer's Disease Center (MADC) Developmental Project awarded!
Mar 7, 2023
Thrilled to announce that we have been awarded Michigan Alzheimer's Disease Center (MADC) Developmental Project grant for our ongoing AD research. We appreciate the significant support from MADC/MADRC (https://alzheimers.med.umich.edu/).
Alzheimer's Association Research Grant (AARG) awarded!
Feb 22, 2023
Thrilled to announce that we have been awarded an Alzheimer's Association Research Grant (AARG) for our ongoing research. With this support, we aim to understand how compartmental protein demand and homeostasis are modified in Alzheimer’s disease models. We appreciate the significant support from the Alzheimer's Association (www.alz.org). #ENDALZ
Link: https://today.wayne.edu/medicine/news/2023/05/30/alzheimers-association-supports-synaptic-research-by-school-of-medicines-joongkyu-park-phd-53509
Anna is awarded WSU Pharmacology SNAP funding! Congrats!
Jan 27, 2023
Bridget is selected as a recipient of the 2023 UROP Winter-Spring/Summer Award! Congrats!
Jan 19, 2023
Anna is selected as the Pharmacology Image Contest Winners! Congrats!
Aug 29, 2022
Anna is selected as a recipient of the Corrine F. Resta Endowed Doctoral Support Award! Congrats!
Aug 25, 2022
Joongkyu is selected as a recipient of the Wayne State University School of Medicine's College Teaching Award. Congrats!
Aug 22, 2022
New paper is out!
August 19, 2022
NMDA receptor-targeted enrichment of CaMKIIα improves fear memory.
Chifor A, Choi J, Park J.
iScience (2022) 25: 104864. doi:10.1016/j.isci.2022.104864
"Capitalizing on the fact that long-term potentiation requires N-methyl-D-aspartate receptors (NMDARs) and Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα), we develop an intrabody that targets NMDARs and show that intrabody-mediated postsynaptic enrichment of CaMKIIα in the hippocampus improves contextual fear memory. "
https://pubmed.ncbi.nlm.nih.gov/35996578/
Joongkyu is selected as a recipient of the Isadore & Margaret Mezey Junior Investigator Conference Award. Congrats!
May 2, 2022
Sana is inducted into Phi Beta Kappa, the oldest academic honor society in the US! Congrats!
2022
Anna is selected as NIH-funded Chemistry Biology Interface (CBI) Scholar for the 2022-2023! Congrats!
2022
Anthony won the 1st Place in the Basic Science Research of the 2022 Medical Student Research Symposium! Congrats!
February 15, 2021
Anthony's got the WSU SOM 2021 Medical Student Research Fellowship! Congrats!
May 21, 2021
Anthony is the 1st Place Winner of Basic Science Research of the 2021 Medical Student Research Virtual Symposium!
February 12, 2021
The 2021 Medical Student Research Virtual Symposium at Wayne State University School of Medicine announced today that Anthony Chifor is the recipient of the 1st place winner of the Basic Science Research for the development of novel, genetically encoded tools. Congratulations, Anthony!
NIH/NIA R21 grant awarded!
August 1, 2020
Thrilled to announce that we have been awarded a R21 grant (R21AG068423). We appreciate the significant support from the National Institutes of Health (NIH)/National Institute on Aging (NIA).
New paper is out!
October 08, 2018
Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity.
Park J.
Proteomes (2018) 6: 40. Review. doi: 10.3390/proteomes6040040
• Special Issue "Neuroproteomics"
"This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity."
https://pubmed.ncbi.nlm.nih.gov/30297624/
Park lab is open!
September 01, 2018
Park lab (www.synapsepark.com) is open! We start an adventure to understand synaptic molecular dynamics underlying normal and pathological behavioral processes.