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Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.

Park J, Berthoux C, Hoyos-Ramirez E, Shan L, Morimoto-Tomita M, Wang Y, Castillo PE, Tomita S.

Cell Rep (2023) 42: 112826. doi:10.1016/j.celrep.2023.112826 PMID: 37471228 PMCID: PMC10528344

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.

Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Zhang J, Walther TC, Farese RV Jr.

Nat Cell Biol (2023) 25: 1101-1110. doi:10.1038/s41556-023-01178-w PMID: 37443287 PMCID: PMC10415183

Highlighted in Hurtley S (2023) Cell Biology: Spartin mediates lipophagy. Science doi:10.1126/science.add3509.

Highlighted in Metur SP, Klionsky DJ (2023) SPART links autophagy machinery and lipid droplets in motor neurons. Autophagy PMID: 37573517 doi:10.1080/15548627.2023.2247311.

Highlighted in Wong W (2023) A spartin approach to lipophagy. Sci Signal PMID: 37699079 doi:10.1126/scisignal.adk7152doi:10.1080/15548627.2023.2247311.

NMDA receptor-targeted enrichment of CaMKIIα improves fear memory.

Chifor A, Choi J, Park J.

iScience (2022) 25: 104864. doi:10.1016/j.isci.2022.104864 PMID: 35996578 PMCID: PMC9391594

Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.

Lee YH, Im E, Hyun M, Park J, Chung KC.

J Biol Chem (2021) 296: 100245. doi:10.1074/jbc.RA120.015574 PMID: 33380426 PMCID: PMC7948726

TMEM163 regulates ATP-gated P2X receptor and behavior.

Salm EJ, Dunn PJ, Shan L, Yamasaki M, Malewicz NM, Miyazaki T, Park J, Sumioka A, Hamer RRL, He WW, Morimoto-Tomita M, LaMotte RH, Tomita S.

Cell Rep (2020) 31: 107704. doi:10.1016/j.celrep.2020.107704 PMID: 32492420 PMCID: PMC7337098

Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity.

Park J.
Proteomes (2018) 6: 40. Review. doi:10.3390/proteomes6040040 PMID: 30297624 PMCID: PMC6313930

Special Issue "Neuroproteomics"

CaMKII phosphorylation of TARPγ-8 is a mediator of LTP and learning and memory.

Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S.

Neuron (2016) 92: 75-83. doi:10.1016/j.neuron.2016.09.002 PMID: 27667007 PMCID: PMC5059846

F1000Prime Recommended.

Highlighted in Lewis S (2016) Synaptic plasticity: TARP target. Nat Rev Neurosci 17: 671.

New perspectives of Dyrk1A role in neurogenesis and neuropathologic features of Down syndrome.

Park J, Chung KC.

Exp Neurobiol (2013) 22: 244-248. Review. doi:10.5607/en.2013.22.4.244 PMID: 24465139 PMCID: PMC3897685


Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP.

Park J, Sung JY, Park J, Song WJ, Chang S, Chung KC.

J Cell Sci (2012) 125: 67-80. doi:10.1242/jcs.086124 PMID: 22250195

ASK1 negatively regulates the 26S proteasome.

Um JW, Im E, Park J, Oh Y, Min B, Lee HJ, Yoon JB, Chung KC.

J Biol Chem (2010) 285: 36434-36446. doi:10.1074/jbc.M110.133777 PMID: 20843792 PMCID: PMC2978573

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.

Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC.

J Biol Chem (2010) 285: 31895-31906. doi:10.1074/jbc.M110.147520 PMID: 20696760 PMCID: PMC2951261

Function and regulation of Dyrk1A: towards understanding Down syndrome.

Park J, Song WJ, Chung KC.

Cell Mol Life Sci (2009) 66: 3235-3240. Review. doi:10.1007/s00018-009-0123-2 PMID: 19685005

Two key genes closely implicated with the neuropathological characteristics in Down syndromeDYRK1A and RCAN1.

Park J, Oh Y, Chung KC.

BMB Reports (2009) 42: 6-15. Review. PMID: 19192387

Down syndrome critical region 2 protein inhibits the transcriptional activity of peroxisome proliferator-activated receptor β in HEK293 cells.

Song HJ, Park J, Seo SR, Kim J, Paik SR, Chung KC.

Biochem Biophys Res Commun (2008) 376: 478-482. doi:10.1016/j.bbrc.2008.09.017 PMID: 18793612

NF-κB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.

Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC.

J Biol Chem (2008) 283: 3392-3400. doi:10.1074/jbc.M706707200 PMID: 18056702

Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome.

Park J, Yang EJ, Yoon JH, Chung KC.

Mol Cell Neurosci (2007) 36: 270-279. doi:10.1016/j.mcn.2007.07.007 PMID: 17720532

α-Synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells.

Sung JY, Lee HJ, Jeong EI, Oh Y, Park J, Kang KS, Chung KC.

Neurosci Lett (2007) 416: 289-293. doi:10.1016/j.neulet.2007.02.025 PMID: 17337120

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